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Philosoraptor - i woner if james is fucked because MDMA has been identified as a potent agonist of TAAR1, a newly discovered GPCR important for regulation of monoaminergic systems in the brainActivation of TAAR1 increases cAMP production via adenylyl cyclase activation and inhibits transporter function.hese effects increase monoamine efflux and prolong the amount of time monoamines remain in the synapse.

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